The role of MyD88 signaling in heterosubtypic influenza A virus infections
Department of Medicine, Division of Infectious Diseases and Immunology
Immunology and Infectious Disease | Virology | Virus Diseases
A mouse model of heterosubtypic influenza A virus infections was used to determine the role of MyD88 signaling in CD4+ T-cell, CD8+ T-cell, and IgG immune responses. We found that MyD88 signaling played an important role in anti-influenza A virus heterosubtypic lung and spleen CD4+ T-cell, and spleen CD8+ T-cell, immune responses. MyD88 dependent signaling was important for T-helper 1 cytokine production in anti-influenza A virus lung and spleen heterosubtypic CD4+ T-cells, but not for their frequencies. Toll-like receptor 7 dependent signaling played a partial role in anti-influenza A virus lung heterosubtypic CD4+ T-helper 1 responses and anti-influenza A virus heterosubtypic IgG2c antibody levels. Our results have important implications for the generation of effective universal influenza vaccines.
DOI of Published Version
Virus Res. 2013 Jan;171(1):216-21. doi: 10.1016/j.virusres.2012.12.004. Link to article on publisher's website
Madera RF, Libraty DH. (2013). The role of MyD88 signaling in heterosubtypic influenza A virus infections. Morningside Graduate School of Biomedical Sciences Student Publications. https://doi.org/10.1016/j.virusres.2012.12.004. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1824