eScholarship@UMMS

Title

Long-term Trends in Short-term Outcomes in Acute Myocardial Infarction

Authors

Hoa L. Nguyen, University of Massachusetts Medical SchoolFollow
Jane S. Saczynski, University of Massachusetts Medical SchoolFollow
Joel M. Gore, University of Massachusetts Medical SchoolFollow
Molly E. Waring, University of Massachusetts Medical SchoolFollow
Darleen M. Lessard, University of Massachusetts Medical SchoolFollow
Jorge L. Yarzebski, University of Massachusetts Medical SchoolFollow
George W. Reed, University of Massachusetts Medical SchoolFollow
Frederick A. Spencer, McMaster University
Shu-Xia Li, Yale-New Haven Hospital
Robert J. Goldberg, University of Massachusetts Medical SchoolFollow

Student Author(s)

Hoa L. Nguyen

GSBS Program

Biochemistry & Molecular Pharmacology

Publication Date

2011-10-01

UMMS Affiliation

Department of Medicine, Division of Cardiovascular Medicine; Department of Quantitative Health Sciences

Document Type

Article

Disciplines

Cardiology | Cardiovascular Diseases | Health Services Research | Life Sciences | Medicine and Health Sciences

Abstract

BACKGROUND: The objectives of this study were to examine the magnitude of, and 20-year trends in, age differences in short-term outcomes among men and women hospitalized with acute myocardial infarction (AMI) in central Massachusetts.

METHODS: The study population consisted of 5907 male and 4406 female residents of the Worcester, MA, metropolitan area hospitalized at all greater Worcester medical centers with AMI between 1986 and 2005.

RESULTS: Overall, among both men and women, older patients were significantly more likely to have developed atrial fibrillation, heart failure, and to have died during hospitalization and within 30 days after admission compared with patients agedmen, age differences in the risk of developing atrial fibrillation have widened over the past 2 decades, while differences in the risk of developing cardiogenic shock have narrowed for men 75 years and older as compared with those agedwomen, age differences in the risk of developing these major complications of AMI have not changed significantly over time. Age differences in short-term mortality have remained relatively unchanged over the past 20 years in both sexes, although individuals of all ages have experienced decreases in short-term death rates over this period.

CONCLUSIONS: Elderly men and women are more likely to experience adverse short-term outcomes after AMI, and age differences in short-term mortality rates have remained relatively unchanged in both sexes over the past 20 years. More targeted treatment approaches during hospitalization for AMI and thereafter are needed for older patients to improve their prognosis.

Keywords

UMCCTS funding

DOI of Published Version

10.1016/j.amjmed.2011.05.023

Source

Am J Med. 2011 Oct;124(10):939-46. Link to article on publisher's website

Journal/Book/Conference Title

The American journal of medicine

Related Resources

Link to article in PubMed

PubMed ID

21962314

Repository Citation

Nguyen, Hoa L.; Saczynski, Jane S.; Gore, Joel M.; Waring, Molly E.; Lessard, Darleen M.; Yarzebski, Jorge L.; Reed, George W.; Spencer, Frederick A.; Li, Shu-Xia; and Goldberg, Robert J., "Long-term Trends in Short-term Outcomes in Acute Myocardial Infarction" (2011). GSBS Student Publications. 1759.
https://escholarship.umassmed.edu/gsbs_sp/1759