The two CRYs of the butterfly
Department of Neurobiology; Reppert Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Neuroscience and Neurobiology
Animal flavoproteins called cryptochromes (CRYs) are generally believed to have distinct circadian clock functions in insects and mammals. We have discovered that the monarch butterfly, Danaus plexippus, has two cry genes: one encodes a fly-like protein with photosensitive properties, while the other encodes a mouse-like protein with potent transcriptional repressive activity. Database searches show that other non-drosophilid insects also have two cry genes. These findings change our view of how some insect clocks may work and redefine the evolution of animal CRYs.
DOI of Published Version
Curr Biol. 2005 Dec 6;15(23):R953-4. Link to article on publisher's site
Current biology : CB
Zhu, Haisun; Yuan, Quan; Briscoe, Adriana D.; Froy, Oren; Casselman, Amy L.; and Reppert, Steven M., "The two CRYs of the butterfly" (2005). GSBS Student Publications. 1733.