GSBS Student Publications
Title
Neuronal death or dismemberment mediated by Sox14
GSBS Program
Neuroscience
UMMS Affiliation
Department of Neurobiology; Freeman Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Date
11-26-2009
Document Type
Article
Medical Subject Headings
Animals; Axons; Cell Differentiation; Dendrites; Drosophila; Drosophila Proteins; Metamorphosis, Biological; Neurons; SOXB2 Transcription Factors
Disciplines
Neuroscience and Neurobiology
Abstract
The pruning of unneeded axons and dendrites is crucial for circuitry maturation, but poorly understood on the molecular level. During Drosophila metamorphosis, the transcription factor Sox14 acts as a context-dependent mediator of death, axonal or dendritic pruning. Its transcriptional target Mical acts specifically in dendrite pruning.
Rights and Permissions
Citation: Nat Neurosci. 2009 Dec;12(12):1479-80. Link to article on publisher's site
DOI of Published Version
10.1038/nn1209-1479
Related Resources
Journal Title
Nature neuroscience
PubMed ID
19935724
Repository Citation
Osterloh, Jeannette M. and Freeman, Marc R., "Neuronal death or dismemberment mediated by Sox14" (2009). GSBS Student Publications. 1715.
https://escholarship.umassmed.edu/gsbs_sp/1715