Neuronal death or dismemberment mediated by Sox14
Department of Neurobiology; Freeman Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Neuroscience and Neurobiology
The pruning of unneeded axons and dendrites is crucial for circuitry maturation, but poorly understood on the molecular level. During Drosophila metamorphosis, the transcription factor Sox14 acts as a context-dependent mediator of death, axonal or dendritic pruning. Its transcriptional target Mical acts specifically in dendrite pruning.
DOI of Published Version
Nat Neurosci. 2009 Dec;12(12):1479-80. Link to article on publisher's site
Osterloh JM, Freeman MR. (2009). Neuronal death or dismemberment mediated by Sox14. GSBS Student Publications. https://doi.org/10.1038/nn1209-1479. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1715