A neural circuit mechanism integrating motivational state with memory expression in Drosophila
Department of Neurobiology; Waddell Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Neuroscience and Neurobiology
Behavioral expression of food-associated memory in fruit flies is constrained by satiety and promoted by hunger, suggesting an influence of motivational state. Here, we identify a neural mechanism that integrates the internal state of hunger and appetitive memory. We show that stimulation of neurons that express neuropeptide F (dNPF), an ortholog of mammalian NPY, mimics food deprivation and promotes memory performance in satiated flies. Robust appetitive memory performance requires the dNPF receptor in six dopaminergic neurons that innervate a distinct region of the mushroom bodies. Blocking these dopaminergic neurons releases memory performance in satiated flies, whereas stimulation suppresses memory performance in hungry flies. Therefore, dNPF and dopamine provide a motivational switch in the mushroom body that controls the output of appetitive memory.
DOI of Published Version
Cell. 2009 Oct 16;139(2):416-27. Link to article on publisher's site
Krashes MJ, DasGupta S, Vreede A, White B, Armstrong JD, Waddell S. (2009). A neural circuit mechanism integrating motivational state with memory expression in Drosophila. GSBS Student Publications. https://doi.org/10.1016/j.cell.2009.08.035. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1712