GSBS Student Publications

Title

The MutS C terminus is essential for mismatch repair activity in vivo

GSBS Program

Biochemistry & Molecular Pharmacology

Publication Date

2005-09-15

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Biochemistry and Molecular Pharmacology; Program in Molecular Medicine

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

An Escherichia coli K-12 strain was constructed with a chromosomal deletion (mutSdelta800) in the mutS gene that produced the removal of the C-terminal 53 amino acids which are not present in the MutS crystal structure. This strain has a MutS null phenotype for mutation avoidance, anti-recombination, and sensitivity to cytotoxic agents in a dam mutant background.

DOI of Published Version

10.1128/JB.187.18.6577-6579.2005

Source

J Bacteriol. 2005 Sep;187(18):6577-9. Link to article on publisher's site

Journal/Book/Conference Title

Journal of bacteriology

Related Resources

Link to article in PubMed

PubMed ID

16159793

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