Title
The MutS C terminus is essential for mismatch repair activity in vivo
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Biochemistry and Molecular Pharmacology; Program in Molecular Medicine
Publication Date
2005-09-15
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
An Escherichia coli K-12 strain was constructed with a chromosomal deletion (mutSdelta800) in the mutS gene that produced the removal of the C-terminal 53 amino acids which are not present in the MutS crystal structure. This strain has a MutS null phenotype for mutation avoidance, anti-recombination, and sensitivity to cytotoxic agents in a dam mutant background.
DOI of Published Version
10.1128/JB.187.18.6577-6579.2005
Source
J Bacteriol. 2005 Sep;187(18):6577-9. Link to article on publisher's site
Journal/Book/Conference Title
Journal of bacteriology
Related Resources
PubMed ID
16159793
Repository Citation
Calmann MA, Nowosielska A, Marinus MG. (2005). The MutS C terminus is essential for mismatch repair activity in vivo. GSBS Student Publications. https://doi.org/10.1128/JB.187.18.6577-6579.2005. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/171