GSBS Student Publications
Title
Cocaine-induced metabolic activation in cortico-limbic circuitry is increased after exposure to the histone deacetylase inhibitor, sodium butyrate
GSBS Program
Neuroscience
Publication Date
2009-07-30
UMMS Affiliation
Department of Psychiatry
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences | Neuroscience and Neurobiology
Abstract
Drug-induced inhibition of histone deacetylase (HDAC) results in the modification of many behavioral changes resulting from exposure to cocaine and other stimulant drugs-of-abuse, but a comprehensive map of the neuronal circuitries involved is lacking. The present study used blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD fMRI) in awake rats to determine the effects of the HDAC inhibitor, sodium butyrate (SBt) on brain metabolic activation patterns during the initial stage of repeated cocaine administration. Three groups of rats received cocaine during BOLD fMRI, (i) acutely for the first time, or pretreated for 2 days with either (ii) saline or (iii) SBt 30 min prior to cocaine. Acute but not repeated exposure to cocaine resulted in widespread BOLD activation in fore- and mid-brain. Pretreatment with SBt restored BOLD signals in the forebrain after repeated cocaine exposure, including a pronounced activation in the anterior thalamus, the hippocampus/amygdala and various portions of limbic and sensory cortex. Mesocorticolimbic areas showed a similar trend, but did not reach statistical significance. These findings suggest that HDACi modulation after repeated stimulant exposure involves cortico-limbic circuitry regulating emotion, motivation and memory.
DOI of Published Version
10.1016/j.neulet.2009.07.065
Source
Neurosci Lett. 2009 Nov 20;465(3):267-71. Epub 2009 Jul 26. Link to article on publisher's site
Journal/Book/Conference Title
Neuroscience letters
Related Resources
PubMed ID
19638299
Repository Citation
Febo, Marcelo; Akbarian, Schahram; Schroeder, Frederick Albert; and Ferris, Craig F., "Cocaine-induced metabolic activation in cortico-limbic circuitry is increased after exposure to the histone deacetylase inhibitor, sodium butyrate" (2009). GSBS Student Publications. 1708.
https://escholarship.umassmed.edu/gsbs_sp/1708