Academic Program
Neuroscience
UMMS Affiliation
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry; Program in Molecular Medicine; Martin Lab
Publication Date
2010-05-28
Document Type
Article
Disciplines
Neuroscience and Neurobiology
Abstract
Histone methyltransferases specific for the histone H3-lysine 9 residue, including Setdb1 (Set domain, bifurcated 1)/Eset/Kmt1e are associated with repressive chromatin remodeling and expressed in adult brain, but potential effects on neuronal function and behavior remain unexplored. Here, we report that transgenic mice with increased Setdb1 expression in adult forebrain neurons show antidepressant-like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness. Chromatin immunoprecipitation in conjunction with DNA tiling arrays (ChIP-chip) revealed that genomic occupancies of neuronal Setdb1 are limited to
Rights and Permissions
Publisher PDF posted after 6 months as allowed by the publisher's author rights policy at http://www.jneurosci.org/sites/default/files/files/JN_License_to_Publish.pdf.
DOI of Published Version
10.1523/JNEUROSCI.1314-10.2010
Source
J Neurosci. 2010 May 26;30(21):7152-67. Link to article on publisher's site
Journal/Book/Conference Title
The Journal of neuroscience : the official journal of the Society for Neuroscience
Related Resources
PubMed ID
20505083
Repository Citation
Jiang Y, Jakovcevski M, Bharadwaj R, Connor CM, Schroeder FA, Lin CL, Straubhaar JR, Martin GE, Akbarian S. (2010). Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B. GSBS Student Publications. https://doi.org/10.1523/JNEUROSCI.1314-10.2010. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1694