Brudnick Neuropsychiatric Research Institute, Department of Psychiatry; Program in Molecular Medicine
Life Sciences | Medicine and Health Sciences | Neuroscience and Neurobiology
Histone methyltransferases specific for the histone H3-lysine 9 residue, including Setdb1 (Set domain, bifurcated 1)/Eset/Kmt1e are associated with repressive chromatin remodeling and expressed in adult brain, but potential effects on neuronal function and behavior remain unexplored. Here, we report that transgenic mice with increased Setdb1 expression in adult forebrain neurons show antidepressant-like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness. Chromatin immunoprecipitation in conjunction with DNA tiling arrays (ChIP-chip) revealed that genomic occupancies of neuronal Setdb1 are limited to
DOI of Published Version
J Neurosci. 2010 May 26;30(21):7152-67. Link to article on publisher's site
The Journal of neuroscience : the official journal of the Society for Neuroscience
Jiang, Yan; Jakovcevski, Mira; Bharadwaj, Rahul; Connor, Caroline M.; Schroeder, Frederick Albert; Lin, Cong L.; Straubhaar, Juerg R.; Martin, Gilles E.; and Akbarian, Schahram, "Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B" (2010). GSBS Student Publications. 1694.