Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B
Authors
Jiang, YanJakovcevski, Mira
Bharadwaj, Rahul
Connor, Caroline M.
Schroeder, Frederick Albert
Lin, Cong L.
Straubhaar, Juerg R.
Martin, Gilles E.
Akbarian, Schahram
Student Authors
Yan Jiang; Caroline Connor; Frederick SchroederUMass Chan Affiliations
Martin LabProgram in Molecular Medicine
Brudnick Neuropsychiatric Research Institute
Department of Psychiatry
Graduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2010-05-28Keywords
Adaptation, Ocular; Affect; Age Factors; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Chromatin; Chromatin Immunoprecipitation; Conditioning (Psychology); Electroshock; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Exploratory Behavior; Fear; Food Preferences; Gene Expression Regulation; Green Fluorescent Proteins; Hippocampus; Humans; Immobility Response, Tonic; Maze Learning; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neurons; Patch-Clamp Techniques; Protein Methyltransferases; RNA, Small Interfering; Receptors, N-Methyl-D-Aspartate; Sucrose; Sweetening Agents; TransfectionNeuroscience and Neurobiology
Metadata
Show full item recordAbstract
Histone methyltransferases specific for the histone H3-lysine 9 residue, including Setdb1 (Set domain, bifurcated 1)/Eset/Kmt1e are associated with repressive chromatin remodeling and expressed in adult brain, but potential effects on neuronal function and behavior remain unexplored. Here, we report that transgenic mice with increased Setdb1 expression in adult forebrain neurons show antidepressant-like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness. Chromatin immunoprecipitation in conjunction with DNA tiling arrays (ChIP-chip) revealed that genomic occupancies of neuronal Setdb1 are limited toSource
J Neurosci. 2010 May 26;30(21):7152-67. Link to article on publisher's site
DOI
10.1523/JNEUROSCI.1314-10.2010Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33153PubMed ID
20505083Related Resources
Rights
Publisher PDF posted after 6 months as allowed by the publisher's author rights policy at http://www.jneurosci.org/sites/default/files/files/JN_License_to_Publish.pdf.ae974a485f413a2113503eed53cd6c53
10.1523/JNEUROSCI.1314-10.2010