GSBS Student Publications

Student Author(s)

Yan Jiang; Caroline Connor; Frederick Schroeder

GSBS Program

Neuroscience

Publication Date

2010-05-28

UMMS Affiliation

Brudnick Neuropsychiatric Research Institute, Department of Psychiatry; Program in Molecular Medicine; Martin Lab

Document Type

Article

Disciplines

Neuroscience and Neurobiology

Abstract

Histone methyltransferases specific for the histone H3-lysine 9 residue, including Setdb1 (Set domain, bifurcated 1)/Eset/Kmt1e are associated with repressive chromatin remodeling and expressed in adult brain, but potential effects on neuronal function and behavior remain unexplored. Here, we report that transgenic mice with increased Setdb1 expression in adult forebrain neurons show antidepressant-like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness. Chromatin immunoprecipitation in conjunction with DNA tiling arrays (ChIP-chip) revealed that genomic occupancies of neuronal Setdb1 are limited to

Rights and Permissions

Publisher PDF posted after 6 months as allowed by the publisher's author rights policy at http://www.jneurosci.org/sites/default/files/files/JN_License_to_Publish.pdf.

DOI of Published Version

10.1523/JNEUROSCI.1314-10.2010

Source

J Neurosci. 2010 May 26;30(21):7152-67. Link to article on publisher's site

Journal/Book/Conference Title

The Journal of neuroscience : the official journal of the Society for Neuroscience

Related Resources

Link to Article in PubMed

PubMed ID

20505083

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