GSBS Student Publications
Title
Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling
GSBS Program
Neuroscience
Publication Date
2011-02-01
UMMS Affiliation
Department of Neurobiology; Waddell Lab; Alkema Lab; Budnik Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Document Type
Article
Disciplines
Behavioral Neurobiology | Developmental Neuroscience | Molecular and Cellular Neuroscience | Neuroscience and Neurobiology
Abstract
Adrenergic signaling has important roles in synaptic plasticity and metaplasticity. However, the underlying mechanisms of these functions remain poorly understood. We investigated the role of octopamine, the invertebrate counterpart of adrenaline and noradrenaline, in synaptic and behavioral plasticity in Drosophila. We found that an increase in locomotor speed induced by food deprivation was accompanied by an activity- and octopamine-dependent extension of octopaminergic arbors and that the formation and maintenance of these arbors required electrical activity. Growth of octopaminergic arbors was controlled by a cAMP- and CREB-dependent positive-feedback mechanism that required Octβ2R octopamine autoreceptors. Notably, this autoregulation was necessary for the locomotor response. In addition, octopamine neurons regulated the expansion of excitatory glutamatergic neuromuscular arbors through Octβ2Rs on glutamatergic motor neurons. Our results provide a mechanism for global regulation of excitatory synapses, presumably to maintain synaptic and behavioral plasticity in a dynamic range.
DOI of Published Version
10.1038/nn.2716
Source
Nat Neurosci. 2011 Feb;14(2):190-9. Epub 2010 Dec 26. Link to article on publisher's website
Journal/Book/Conference Title
Nature Neuroscience
Related Resources
PubMed ID
21186359
Repository Citation
Koon, Alex C.; Ashley, James A.; Barria, Romina; DasGupta, Shamik; Brain, Ruth; Waddell, Scott; Alkema, Mark J.; and Budnik, Vivian, "Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling" (2011). GSBS Student Publications. 1681.
https://escholarship.umassmed.edu/gsbs_sp/1681