Student Author(s)

Hilary Placzek

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date


Document Type

Article Postprint


Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences


Vaccine effectiveness (VE) studies provide a measure of population-based vaccine performance by combining immunization history data with rates of disease incidence. This review assessed the feasibility of using electronic immunization registry data sources in VE studies. Electronic databases were searched through January 31, 2010. Out of 17 studies, only one paper assessed data accuracy (71%), and three papers assessed population coverage of the registry (estimates ranged from 25% to 90%). This review shows that registry-based data sources can be used to conduct VE studies in a variety of settings and populations. However, we found little information regarding the quality of this data source in VE studies and future evaluations should investigate their reliability, accuracy, and potential bias. Copyright © 2010 Elsevier Ltd. All rights reserved.

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This is the authors' final, peer-reviewed version of the article as prepared for publication in Vaccine, Volume 29, Issue 3, 10 January 2011, Pages 399-411. doi:10.1016/j.vaccine.2010.11.007. View the publisher’s formatted version

DOI of Published Version



Vaccine, Volume 29, Issue 3, 10 January 2011, Pages 399-411. doi: 10.1016/j.vaccine.2010.11.007. View the publisher’s formatted version

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Link to article in PubMed

PubMed ID