Student Author(s)

H. Efsun Arda; Colin C. Conine

Academic Program

Interdisciplinary Graduate Program

UMMS Affiliation

Program in Gene Function and Expression; Program in Molecular Medicine

Publication Date

2010-05-11

Document Type

Article

Disciplines

Genetics and Genomics | Life Sciences | Medicine and Health Sciences

Abstract

Gene regulatory networks (GRNs) provide insights into the mechanisms of differential gene expression at a systems level. GRNs that relate to metazoan development have been studied extensively. However, little is still known about the design principles, organization and functionality of GRNs that control physiological processes such as metabolism, homeostasis and responses to environmental cues. In this study, we report the first experimentally mapped metazoan GRN of Caenorhabditis elegans metabolic genes. This network is enriched for nuclear hormone receptors (NHRs). The NHR family has greatly expanded in nematodes: humans have 48 NHRs, but C. elegans has 284, most of which are uncharacterized. We find that the C. elegans metabolic GRN is highly modular and that two GRN modules predominantly consist of NHRs. Network modularity has been proposed to facilitate a rapid response to different cues. As NHRs are metabolic sensors that are poised to respond to ligands, this suggests that C. elegans GRNs evolved to enable rapid and adaptive responses to different cues by a concurrence of NHR family expansion and modular GRN wiring.

DOI of Published Version

10.1038/msb.2010.23

Source

Molecular Systems Biology 6:367, doi:10.1038/msb.2010.23. Published online: 11 May 2010.

Journal/Book/Conference Title

Molecular Systems Biology

Related Resources

Link to article in PubMed

PubMed ID

20461074

Download

Share

COinS