Title
Gene-centered regulatory networks
Academic Program
Interdisciplinary Graduate Program
UMMS Affiliation
Program in Gene Function and Expression
Publication Date
2010-1
Document Type
Article
Disciplines
Genetics and Genomics | Life Sciences | Medicine and Health Sciences
Abstract
Differential gene expression plays a critical role in the development and physiology of multicellular organisms. At a 'systems level' (e.g. at the level of a tissue, organ or whole organism), this process can be studied using gene regulatory network (GRN) models that capture physical and regulatory interactions between genes and their regulators. In the past years, significant progress has been made toward the mapping of GRNs using a variety of experimental and computational approaches. Here, we will discuss gene-centered approaches that we employed to characterize GRNs and describe insights that we have obtained into the global design principles of gene regulation in complex metazoan systems.
DOI of Published Version
10.1093/bfgp/elp049
Source
Briefings in Functional Genomics 2010 9(1):4-12; doi:10.1093/bfgp/elp049.
Journal/Book/Conference Title
Briefings in Functional Genomics
Related Resources
PubMed ID
20008400
Repository Citation
Arda HE, Walhout AJ. (2010). Gene-centered regulatory networks. GSBS Student Publications. https://doi.org/10.1093/bfgp/elp049. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1647