Student Authors
H. Efsun ArdaUMass Chan Affiliations
Program in Gene Function and ExpressionDocument Type
Journal ArticlePublication Date
2010-01-01Keywords
Transcription Factors; Gene Expression Regulation; Gene Regulatory Networks; Caenorhabditis elegans; Two-Hybrid System TechniquesGenetics and Genomics
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Differential gene expression plays a critical role in the development and physiology of multicellular organisms. At a 'systems level' (e.g. at the level of a tissue, organ or whole organism), this process can be studied using gene regulatory network (GRN) models that capture physical and regulatory interactions between genes and their regulators. In the past years, significant progress has been made toward the mapping of GRNs using a variety of experimental and computational approaches. Here, we will discuss gene-centered approaches that we employed to characterize GRNs and describe insights that we have obtained into the global design principles of gene regulation in complex metazoan systems.Source
Briefings in Functional Genomics 2010 9(1):4-12; doi:10.1093/bfgp/elp049.
DOI
10.1093/bfgp/elp049Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33103PubMed ID
20008400Related Resources
ae974a485f413a2113503eed53cd6c53
10.1093/bfgp/elp049