GSBS Student Publications

Title

TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.

Student Author(s)

David M. Miller

Publication Date

2008-12-01

UMMS Affiliation

Department of Medicine, Division of Diabetes; Department of Pathology; Program in Molecular Medicine

Document Type

Article

Disciplines

Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences

Abstract

We investigated the mechanisms by which Toll-like receptor (TLR) agonists affect the induction of mixed chimerism and skin allograft survival in mice treated with co-stimulation blockade (CB). We report that TLR agonists prevent the generation of mixed chimerism by breaking tolerance in the alloreactive CD4(+) and CD8(+) T cell compartments, and that type I interferon (IFN) is important in this process. Understanding how environmental perturbations affect CB-induced transplantation tolerance may lead to more effective regimens that can be used as an approach for the treatment of type I diabetes, for which the transplantation of pancreatic islets is a promising therapy.

Source

Ann N Y Acad Sci. 2008 Dec;1150:149-51.

Journal/Book/Conference Title

Annals of the New York Academy of Sciences

Related Resources

Link to article in PubMed

PubMed ID

19120285

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