GSBS Student Publications


Role of innate immunity in transplantation tolerance.

Student Author(s)

David M. Miller

UMMS Affiliation

Department of Medicine, Division of Diabetes



Document Type


Medical Subject Headings

Animals; Graft Rejection; Histocompatibility Testing; Humans; Immunity, Innate; Lymphocyte Activation; Receptors, Pattern Recognition; Signal Transduction; T-Lymphocytes; Toll-Like Receptors; Transplantation Chimera; Transplantation Tolerance; Transplantation, Homologous


Immunity | Life Sciences | Medicine and Health Sciences


Allogeneic organ transplantation has proven to be an effective therapeutic strategy for patients with end-stage organ disease. However, the chronic immunosuppression that is required for the survival of the allograft increases the risk for infection and malignancy. The establishment of transplantation tolerance, defined functionally as the survival of a donor allograft in the absence of immunosuppression, is the ultimate goal in the field of transplantation. Transplantation tolerance can be achieved using approaches that induce peripheral and/or central tolerance to the allograft. Protocols based on costimulation blockade (CB) have emerged as some of the most promising protocols for inducing long-term allograft survival in the absence of chronic immunosuppression. Despite its potential, recent evidence suggests that the efficacy of costimulation blockade can be reduced by environmental perturbations such as infection or inflammation, which activate Toll-like receptors (TLR). In this review, we discuss how the activation of TLRs can affect the induction and maintenance of transplantation tolerance.

Rights and Permissions

Citation: Crit Rev Immunol. 2008;28(5):403-39.

Related Resources

Link to article in PubMed

Journal Title

Critical reviews in immunology

PubMed ID