Student Authors
David M. MillerUMass Chan Affiliations
Department of Medicine, Division of DiabetesDocument Type
Journal ArticlePublication Date
2008-01-01Keywords
Animals; Graft Rejection; Histocompatibility Testing; Humans; Immunity, Innate; Lymphocyte Activation; Receptors, Pattern Recognition; Signal Transduction; T-Lymphocytes; Toll-Like Receptors; Transplantation Chimera; Transplantation Tolerance; Transplantation, HomologousImmunity
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Allogeneic organ transplantation has proven to be an effective therapeutic strategy for patients with end-stage organ disease. However, the chronic immunosuppression that is required for the survival of the allograft increases the risk for infection and malignancy. The establishment of transplantation tolerance, defined functionally as the survival of a donor allograft in the absence of immunosuppression, is the ultimate goal in the field of transplantation. Transplantation tolerance can be achieved using approaches that induce peripheral and/or central tolerance to the allograft. Protocols based on costimulation blockade (CB) have emerged as some of the most promising protocols for inducing long-term allograft survival in the absence of chronic immunosuppression. Despite its potential, recent evidence suggests that the efficacy of costimulation blockade can be reduced by environmental perturbations such as infection or inflammation, which activate Toll-like receptors (TLR). In this review, we discuss how the activation of TLRs can affect the induction and maintenance of transplantation tolerance.Source
Crit Rev Immunol. 2008;28(5):403-39.
DOI
10.1615/CritRevImmunol.v28.i5.30Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33053PubMed ID
19166387Related Resources
ae974a485f413a2113503eed53cd6c53
10.1615/CritRevImmunol.v28.i5.30