GSBS Student Publications

Title

Structural analysis of human immunodeficiency virus type 1 CRF01_AE protease in complex with the substrate p1-p6.

Publication Date

2008-07-01

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Document Type

Article

Disciplines

Life Sciences | Medical Biochemistry | Medical Biophysics | Medicine and Health Sciences

Abstract

The effect of amino acid variability between human immunodeficiency virus type 1 (HIV-1) clades on structure and the emergence of resistance mutations in HIV-1 protease has become an area of significant interest in recent years. We determined the first crystal structure of the HIV-1 CRF01_AE protease in complex with the p1-p6 substrate to a resolution of 2.8 A. Hydrogen bonding between the flap hinge and the protease core regions shows significant structural rearrangements in CRF01_AE protease compared to the clade B protease structure.

DOI of Published Version

10.1128/JVI.00018-08

Source

J Virol. 2008 Jul;82(13):6762-6. Link to article on publisher's website

Journal/Book/Conference Title

Journal of virology

Related Resources

Link to article in PubMed

PubMed ID

18434392

Share

COinS