Title
Structural analysis of human immunodeficiency virus type 1 CRF01_AE protease in complex with the substrate p1-p6.
UMMS Affiliation
Department of Biochemistry and Molecular Pharmacology
Publication Date
2008-07-01
Document Type
Article
Disciplines
Life Sciences | Medical Biochemistry | Medical Biophysics | Medicine and Health Sciences
Abstract
The effect of amino acid variability between human immunodeficiency virus type 1 (HIV-1) clades on structure and the emergence of resistance mutations in HIV-1 protease has become an area of significant interest in recent years. We determined the first crystal structure of the HIV-1 CRF01_AE protease in complex with the p1-p6 substrate to a resolution of 2.8 A. Hydrogen bonding between the flap hinge and the protease core regions shows significant structural rearrangements in CRF01_AE protease compared to the clade B protease structure.
DOI of Published Version
10.1128/JVI.00018-08
Source
J Virol. 2008 Jul;82(13):6762-6. Link to article on publisher's website
Journal/Book/Conference Title
Journal of virology
Related Resources
PubMed ID
18434392
Repository Citation
Bandaranayake RM, Prabu-Jeyabalan M, Kakizawa J, Sugiura W, Schiffer CA. (2008). Structural analysis of human immunodeficiency virus type 1 CRF01_AE protease in complex with the substrate p1-p6.. GSBS Student Publications. https://doi.org/10.1128/JVI.00018-08. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1595