GSBS Student Publications

Title

A Tyramine-Gated Chloride Channel Coordinates Distinct Motor Programs of a Caenorhabditis elegans Escape Response

Student Author(s)

Jennifer Pirri; Jamie Donnelly

GSBS Program

Neuroscience

Publication Date

2009-05-28

UMMS Affiliation

Department of Neurobiology; Alkema Lab; Francis Lab; Graduate School of Biomedical Sciences, Neuroscience Program

Document Type

Article

Disciplines

Neuroscience and Neurobiology

Abstract

A key feature of escape responses is the fast translation of sensory information into a coordinated motor output. In C. elegans, anterior touch initiates a backward escape response in which lateral head movements are suppressed. Here, we show that tyramine inhibits head movements and forward locomotion through the activation of a tyramine-gated chloride channel, LGC-55. lgc-55 mutant animals have defects in reversal behavior and fail to suppress head oscillations in response to anterior touch. lgc-55 is expressed in neurons and muscle cells that receive direct synaptic inputs from tyraminergic motor neurons. Therefore, tyramine can act as a classical inhibitory neurotransmitter. Activation of LGC-55 by tyramine coordinates the output of two distinct motor programs, locomotion and head movements that are critical for a C. elegans escape response.

DOI of Published Version

10.1016/j.neuron.2009.04.013

Source

Pirri, J.K., McPherson, A.D., Donnelly, J.L., Francis, M.M., and Alkema, M.J. (2009). A Tyramine-Gated Chloride Channel Coordinates Distinct Motor Programs of a Caenorhabditis elegans Escape Response. Neuron. 62, 528-536. Link to article on publisher's website

Journal/Book/Conference Title

Neuron

Comments

Article's Supplemental Data include six figures and five movies and can be found with this article online.

Related Resources

Link to article in PubMed

PubMed ID

19477154

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