Title
Intrinsic and synaptic long-term depression of NTS relay of nociceptin- and capsaicin-sensitive cardiopulmonary afferents hyperactivity
UMMS Affiliation
Graduate School of Biomedical Sciences; Program in Neuroscience; Harvard-MIT Division of Health Sciences and Technology
Publication Date
2008-08-16
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
The nucleus tractus solitarius (NTS) in the caudal medulla is a gateway for a variety of cardiopulmonary afferents important for homeostatic regulation and defense against airway and cardiovascular insults and is a key central target potentially mediating the response habituation to these inputs. Here, whole-cell and field population action potential recordings and infrared imaging in rat brainstem slices in vitro revealed a compartmental pain-pathway-like organization of capsaicin-facilitated vs. nocistatin-facilitated/nociceptin-suppressed neuronal clusters in an NTS region, which receives cardiopulmonary A- and C-fiber afferents with differing capsaicin sensitivities. All capsaicin-sensitive neurons and a fraction of nociceptin-sensitive neurons expressed N-methyl-D: -aspartate (NMDA) receptor-dependent synaptic long-term depression (LTD) following afferent stimulation. All neurons also expressed activity-dependent decrease of excitability (intrinsic LTD), which converted to NMDA receptor-dependent intrinsic long-term potentiation after GABA(A) receptor blockade. Thus, distinct intrinsic and synaptic LTD mechanisms in the NTS specific to the relay of A- or C-fiber afferents may underlie the response habituation to persistent afferents hyperactivity that are associated with varying physiologic challenges and cardiopulmonary derangements-including hypertension, chronic cough, asthmatic bronchoconstriction, sustained elevated lung volume in chronic obstructive pulmonary disease or in continuous positive-airway-pressure therapy for sleep apnea, metabolic acidosis, and prolonged exposure to hypoxia at high altitude.
DOI of Published Version
10.1007/s00424-008-0571-9
Source
Pflugers Arch. 2008 Aug 14. Link to article on publisher's site
Journal/Book/Conference Title
Pflugers Archiv : European journal of physiology
Related Resources
PubMed ID
18704488
Repository Citation
Bantikyan A, Song G, Feinberg-Zadek PL, Poon C. (2008). Intrinsic and synaptic long-term depression of NTS relay of nociceptin- and capsaicin-sensitive cardiopulmonary afferents hyperactivity. GSBS Student Publications. https://doi.org/10.1007/s00424-008-0571-9. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1580