Title
Molecular switches involving homeodomain proteins, HOXA10 and RUNX2 regulate osteoblastogenesis
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center
Publication Date
2008-08-15
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
The osteoinductive BMP2 signal facilitates commitment to the osteoblast phenotype by inducing several classes of early response genes. Among these are bone-related HOX factors, homeodomain, RUNX and OSTERIX proteins. Here we demonstrate molecular events among BMP2-induced transcription factors that constitute a network of molecular switches on promoters of bone-related genes to coordinate their temporal expression during cellular differentiation. Our studies provide evidence for (1) selective association of HOXA10, MSX2, DLX3 and DLX5 homeodomain transcription factors on Runx2 and OC genes at stages of osteoblast maturation as well as (2) participation of these factors with RUNX2 in chromatin remodeling of bone-specific genes for repression, activation and attenuation of transcription. These findings reveal the requirement for multiple levels of control for the appropriate timing of osteoblast-related gene expression.
DOI of Published Version
10.1159/000151453
Source
Cells Tissues Organs. 2009;189(1-4):122-5. Epub 2008 Aug 14. Link to article on publisher's site
Journal/Book/Conference Title
Cells, tissues, organs
Related Resources
PubMed ID
18701816
Repository Citation
Hassan MQ, Saini S, Gordon JA, Van Wijnen AJ, Montecino MA, Stein JL, Stein GS, Lian JB. (2008). Molecular switches involving homeodomain proteins, HOXA10 and RUNX2 regulate osteoblastogenesis. GSBS Student Publications. https://doi.org/10.1159/000151453. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1578