Title
Vesicular stomatitis virus matrix protein impairs CD1d-mediated antigen presentation through activation of the p38 MAPK pathway
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Pathology; Department of Microbiology and Immunology
Publication Date
2008-09-26
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Natural killer T (NKT) cells are unique T lymphocytes that recognize CD1d-bound lipid antigens and play an important role in both innate and acquired immune responses against infectious diseases and tumors. We have already shown that a vesicular stomatitis virus (VSV) infection results in the rapid inhibition of murine CD1d-mediated antigen presentation to NKT cells. In the present study, it was found that the VSV matrix (VSV-M) protein is an important element in this decrease in antigen presentation postinfection. The VSV-M protein altered the intracellular distribution of murine CD1d molecules, resulting in qualitative (but not quantitative) changes in cell surface CD1d expression. The M protein was distributed throughout the infected cell, and it was found to activate the mitogen-activated protein kinase (MAPK) p38 very early postinfection. Infection of CD1d(+) cells with a temperature-sensitive VSV-M mutant at the nonpermissive temperature both substantially reversed the inhibition of antigen presentation by CD1d and delayed the activation of p38. Thus, the VSV-M protein plays an important role in permitting the virus to evade important components of the innate immune response by regulating specific MAPK pathways.
DOI of Published Version
10.1128/JVI.00881-08
Source
J Virol. 2008 Dec;82(24):12535-42. Epub 2008 Sep 24. Link to article on publisher's site
Journal/Book/Conference Title
Journal of virology
Related Resources
PubMed ID
18815300
Repository Citation
Renukaradhya GJ, Khan MA, Shaji D, Brutkiewicz RR. (2008). Vesicular stomatitis virus matrix protein impairs CD1d-mediated antigen presentation through activation of the p38 MAPK pathway. Morningside Graduate School of Biomedical Sciences Student Publications. https://doi.org/10.1128/JVI.00881-08. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1561