Title
Nephrogenic systemic fibrosis: an epidemic of gadolinium toxicity
UMMS Affiliation
Graduate School of Biomedical Sciences; Division of Rheumatology
Publication Date
2008-07-22
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Nephrogenic systemic fibrosis is a devastating systemic fibrosing disorder that afflicts patients with renal dysfunction. Growing evidence supports the hypothesis that gadolinium-containing contrast agents (GCCAs) trigger the development of nephrogenic systemic fibrosis. Hence, this condition is most appropriately called gadolinium---associated systemic fibrosis (GASF). In this report, we review the history of GASF, its association with prior GCCA exposure, its clinicopathologic features, the relevant pharmacology of GCCAs, the likely role of GCCAs in its pathogenesis, and potential treatments.
Source
Curr Rheumatol Rep. 2008 Jul;10(3):195-204.
Journal/Book/Conference Title
Current rheumatology reports
Related Resources
PubMed ID
18638427
Repository Citation
Todd DJ, Kay J. (2008). Nephrogenic systemic fibrosis: an epidemic of gadolinium toxicity. GSBS Student Publications. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1544