GSBS Student Publications
Title
Nephrogenic systemic fibrosis: an epidemic of gadolinium toxicity
UMMS Affiliation
Graduate School of Biomedical Sciences; Division of Rheumatology
Date
7-22-2008
Document Type
Article
Medical Subject Headings
Contrast Media; Fibrosis; Gadolinium; Humans; Kidney; Kidney Failure, Chronic; Skin; Skin Diseases
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Nephrogenic systemic fibrosis is a devastating systemic fibrosing disorder that afflicts patients with renal dysfunction. Growing evidence supports the hypothesis that gadolinium-containing contrast agents (GCCAs) trigger the development of nephrogenic systemic fibrosis. Hence, this condition is most appropriately called gadolinium---associated systemic fibrosis (GASF). In this report, we review the history of GASF, its association with prior GCCA exposure, its clinicopathologic features, the relevant pharmacology of GCCAs, the likely role of GCCAs in its pathogenesis, and potential treatments.
Rights and Permissions
Citation: Curr Rheumatol Rep. 2008 Jul;10(3):195-204.
Related Resources
Journal Title
Current rheumatology reports
PubMed ID
18638427
Repository Citation
Todd, Derrick James and Kay, Jonathan, "Nephrogenic systemic fibrosis: an epidemic of gadolinium toxicity" (2008). GSBS Student Publications. 1544.
https://escholarship.umassmed.edu/gsbs_sp/1544