Tissue-specific reduction in DC-SIGN expression correlates with progression of pathogenic simian immunodeficiency virus infection
Graduate School of Biomedical Sciences; Division of Comparative Pathology
Medical Subject Headings
Animals; Cell Adhesion Molecules; Cercocebus atys; Disease Progression; Down-Regulation; Lectins, C-Type; Lymphoid Tissue; Macaca mulatta; Macaca nemestrina; Mesentery; Organ Specificity; Receptors, Cell Surface; Simian Acquired Immunodeficiency; Syndrome; Simian immunodeficiency virus
Life Sciences | Medicine and Health Sciences
Studies were undertaken to determine whether previously described reductions in splenic DC-SIGN expression in simian acquired immune deficiency syndrome (AIDS) are limited to pathogenic simian immunodeficiency virus (SIV) infection. DC-SIGN expression was evaluated by immunohistochemistry in lymphoid tissues from AIDS-susceptible Asian macaque monkeys as compared with AIDS-resistant sooty mangabey monkeys in the presence and absence of SIV infection. The phenotype of DC-SIGN+ cells in susceptible and resistant species was identical and most consistent with macrophage identity. Significantly lower levels of DC-SIGN expression were identified in spleen, mesenteric lymph node, and bone marrow of macaques with AIDS (P<0.05). Reduced levels of splenic DC-SIGN correlated significantly with CD4T cell depletion in long-term pathogenic infection of macaques (P<0.01), whereas SIV-infected mangabeys retained high levels of DC-SIGN expression in spleen despite persistent infection. Reduced expression of DC-SIGN in spleen specifically characterizes pathogenic forms of SIV infection, correlates with disease progression, and may contribute to SIV pathogenesis.
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Citation: Dev Comp Immunol. 2008;32(12):1510-21. Epub 2008 Jul 9. Link to article on publisher's site
DOI of Published Version
Developmental and comparative immunology
Yearley, Jennifer Holmes; Kanagy, Sarah; Anderson, Daniel C.; Dalecki, Karen; Pauley, Douglas R.; Suwyn, Carolyn; Donahoe, Robert M.; McClure, Harold M.; and O'Neil, Shawn P., "Tissue-specific reduction in DC-SIGN expression correlates with progression of pathogenic simian immunodeficiency virus infection" (2008). GSBS Student Publications. 1535.