Sweet bays of ERAD
Graduate School of Biomedical Sciences; Department of Biochemistry and Molecular Biology
Life Sciences | Medicine and Health Sciences
Proteins that improperly mature in the endoplasmic reticulum (ER) are dislocated to the cytoplasm for proteasome-mediated destruction. A recent study provides insight into the incompletely understood processes for selection and targeting of aberrant proteins for ER-associated protein degradation. The identification of the ER chaperones GRP94 and BiP as binding partners for the mannose-binding proteins OS-9 and XTP3-B, indicates that these protein complexes bind to aberrant proteins and direct them to the Hrd1 dislocation and ubiquitylation complex in the ER membrane.
DOI of Published Version
Trends Biochem Sci. 2008 Jul;33(7):298-300. Epub 2008 Jun 4. Link to article on publisher's site
Trends in biochemical sciences
Tamura, Taku; Cormier, James H.; and Hebert, Daniel N., "Sweet bays of ERAD" (2008). GSBS Student Publications. 1515.