GSBS Student Publications

Title

Sweet bays of ERAD

Publication Date

2008-06-10

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Biochemistry and Molecular Biology

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Proteins that improperly mature in the endoplasmic reticulum (ER) are dislocated to the cytoplasm for proteasome-mediated destruction. A recent study provides insight into the incompletely understood processes for selection and targeting of aberrant proteins for ER-associated protein degradation. The identification of the ER chaperones GRP94 and BiP as binding partners for the mannose-binding proteins OS-9 and XTP3-B, indicates that these protein complexes bind to aberrant proteins and direct them to the Hrd1 dislocation and ubiquitylation complex in the ER membrane.

DOI of Published Version

10.1016/j.tibs.2008.04.013

Source

Trends Biochem Sci. 2008 Jul;33(7):298-300. Epub 2008 Jun 4. Link to article on publisher's site

Journal/Book/Conference Title

Trends in biochemical sciences

Related Resources

Link to Article in PubMed

PubMed ID

18538572

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