Title
Sweet bays of ERAD
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Biochemistry and Molecular Biology
Publication Date
2008-06-10
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Proteins that improperly mature in the endoplasmic reticulum (ER) are dislocated to the cytoplasm for proteasome-mediated destruction. A recent study provides insight into the incompletely understood processes for selection and targeting of aberrant proteins for ER-associated protein degradation. The identification of the ER chaperones GRP94 and BiP as binding partners for the mannose-binding proteins OS-9 and XTP3-B, indicates that these protein complexes bind to aberrant proteins and direct them to the Hrd1 dislocation and ubiquitylation complex in the ER membrane.
DOI of Published Version
10.1016/j.tibs.2008.04.013
Source
Trends Biochem Sci. 2008 Jul;33(7):298-300. Epub 2008 Jun 4. Link to article on publisher's site
Journal/Book/Conference Title
Trends in biochemical sciences
Related Resources
PubMed ID
18538572
Repository Citation
Tamura T, Cormier JH, Hebert DN. (2008). Sweet bays of ERAD. Morningside Graduate School of Biomedical Sciences Student Publications. https://doi.org/10.1016/j.tibs.2008.04.013. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1515