Title
The reprogramming language of pluripotency
UMMS Affiliation
Graduate School of Biomedical Sciences; Whitehead Institute for Biomedical Research
Publication Date
2008-03-22
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
In metazoans, lineage-specific transcription factors and epigenetic modifiers function to establish and maintain proper gene expression programs during development. Recent landmark studies in both mouse and human have defined a set of transcription factors whose ectopic expression by retroviral transduction is capable of reprogramming a somatic nucleus to the pluripotent state. The identification of factors that are sufficient for the induction of pluripotency suggests that rewiring transcriptional regulatory networks at the molecular level can be used to manipulate cell fate in vitro. These findings have broad implications for understanding development and disease and for the potential use of stem cells in therapeutic applications.
DOI of Published Version
10.1016/j.gde.2008.01.013
Source
Curr Opin Genet Dev. 2008 Apr;18(2):123-9. Epub 2008 Mar 20. Link to article on publisher's site
Journal/Book/Conference Title
Current opinion in genetics and development
Related Resources
PubMed ID
18356040
Repository Citation
Welstead G, Schorderet P, Boyer LA. (2008). The reprogramming language of pluripotency. GSBS Student Publications. https://doi.org/10.1016/j.gde.2008.01.013. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1468