GSBS Student Publications

Title

The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor

Publication Date

2008-03-04

UMMS Affiliation

Graduate School of Biomedical Sciences; Bristol-Myers Squibb

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

A novel structural class of p38alpha MAP kinase inhibitors has been identified via iterative SAR studies of a focused deck screen hit. Optimization of the lead series generated 6e, BMS-640994, a potent and selective p38alpha inhibitor that is orally efficacious in rodent models of acute and chronic inflammation.

DOI of Published Version

10.1016/j.bmcl.2008.02.031

Source

Bioorg Med Chem Lett. 2008 Mar 15;18(6):1762-7. Epub 2008 Feb 16. Link to article on publisher's site

Journal/Book/Conference Title

Bioorganic and medicinal chemistry letters

Related Resources

Link to Article in PubMed

PubMed ID

18313298

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