GSBS Student Publications


Vitamin D control of gene expression: temporal and spatial parameters for organization of the regulatory machinery

GSBS Program

Biochemistry & Molecular Pharmacology

Publication Date


UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology

Document Type



Life Sciences | Medicine and Health Sciences


Vitamin D is a principal modulator of skeletal gene expression, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiologic responsiveness requires combinatorial control, whereas co-regulatory proteins determine the specificity of biologic responsiveness to physiologic cues. It is becoming increasingly evident that regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.

DOI of Published Version



Crit Rev Eukaryot Gene Expr. 2008;18(2):163-72.

Journal/Book/Conference Title

Critical reviews in eukaryotic gene expression

Related Resources

Link to Article in PubMed

PubMed ID