Enhanced susceptibility to cytotoxic T lymphocytes of target cells isolated from virus-infected or interferon-treated mice
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Department of Pathology; Department of Molecular Genetics and Microbiology
Medical Subject Headings
Animals; Bone Marrow; Cells, Cultured; *Cytotoxicity, Immunologic; H-2 Antigens; Interferon Type I; Lymphocytic Choriomeningitis; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; T-Lymphocytes; T-Lymphocytes, Cytotoxic
Life Sciences | Medicine and Health Sciences
Bone marrow cells and thymocytes isolated from virus-infected or interferon (IFN)-treated mice had marked increases in sensitivity to lysis by allospecific cytotoxic T lymphocytes (CTL) and in expression of class I histocompatibility antigens. Cultured fibroblasts treated with IFN in vitro yielded similar findings in addition to having increased sensitivity to lysis by virus-specific CTL. This indicates that virus-induced IFN may condition target cells in vivo for surveillance by CTL.
Rights and Permissions
Citation: J Virol. 1986 Sep;59(3):735-9.
Journal of virology
Bukowski, Jack F. and Welsh, Raymond M., "Enhanced susceptibility to cytotoxic T lymphocytes of target cells isolated from virus-infected or interferon-treated mice" (1986). GSBS Student Publications. 146.