Interferon enhances the susceptibility of virus-infected fibroblasts to cytotoxic T cells
Graduate School of Biomedical Sciences; Department of Pathology; Department of Molecular Genetics and Microbiology
Life Sciences | Medicine and Health Sciences
Interferon (IFN) pretreatment of low-passage mouse embryonic fibroblasts (MEF) infected with lymphocytic choriomeningitis virus or vaccinia virus rendered these cells two to three times more susceptible to lysis by H-2 restricted, virus-specific cytotoxic T lymphocytes (CTL) than control, virus-infected MEF. The increased sensitivity to lysis correlated with increased expression of surface H-2 antigens, but not viral antigens. Continuous cell lines already highly sensitive to CTL-mediated lysis and already expressing high levels of surface H-2 antigens were unaffected by IFN pretreatment. These results suggest that IFN treatment, by increasing surface H-2 levels, may result in increased association of surface H-2 and virus antigens, leading to enhanced recognition and lysis by virus-specific CTL.
DOI of Published Version
J Exp Med. 1985 Jan 1;161(1):257-62.
The Journal of experimental medicine
Bukowski JF, Welsh RM. (1985). Interferon enhances the susceptibility of virus-infected fibroblasts to cytotoxic T cells. GSBS Student Publications. https://doi.org/10.1084/jem.161.1.257. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/145