GSBS Student Publications
Title
The presence of JAK2V617F in primary myelofibrosis or its allele burden in polycythemia vera predicts chemosensitivity to hydroxyurea
Publication Date
2008-02-13
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Biochemistry and Molecular Biology; Program in Molecular Medicine
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
JAK2V617F-positive patients with essential thrombocythemia, as opposed to their mutation-negative counterparts, require lower doses of hydroxyurea (HU) for control of their platelet count. In the current study, we looked for predictors of HU response in 69 patients with primary myelofibrosis (PMF) and 56 with polycythemia vera (PV). JAK2V617F analysis was performed on bone marrow-derived DNA obtained at or near the time of diagnosis. HU response in PMF was associated with a shorter disease duration (P = 0.008), absence of previous therapy (P = 0.01), older age at diagnosis (P = 0.009), and presence of JAK2V617F (P = 0.02). On multivariable analysis, only the latter retained its significance (48% vs. 8% response in mutation positive vs. negative cases). In PV, JAK2V617F allele burden correlated directly with HU response (P = 0.05) and inversely with daily HU dose in responding patients (P = 0.02). The current study suggests that JAK2V617F presence identifies PMF patients who are likely to respond to HU therapy, and information on its allele burden helps in assigning the optimal starting dose in individual patients with PV.
DOI of Published Version
10.1002/ajh.21149
Source
Am J Hematol. 2008 May;83(5):363-5. Link to article on publisher's site
Journal/Book/Conference Title
American journal of hematology
Related Resources
PubMed ID
18266209
Repository Citation
Sirhan, Shireen; Lasho, Terra L.; Hanson, Curtis A.; Mesa, Ruben A.; Pardanani, Animesh Dev; and Tefferi, Ayalew, "The presence of JAK2V617F in primary myelofibrosis or its allele burden in polycythemia vera predicts chemosensitivity to hydroxyurea" (2008). GSBS Student Publications. 1448.
https://escholarship.umassmed.edu/gsbs_sp/1448