Title
Pruritus in polycythemia vera is associated with a lower risk of arterial thrombosis
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Biochemistry and Molecular Biology; Program in Molecular Medicine
Publication Date
2008-02-08
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Among 418 patients with polycythemia vera seen at our institution and in whom pruritus history was recorded, the presence of pruritus at diagnosis was documented in 131 (31%) and its absence in 287 (69%). Pruritus was less frequently reported by smokers (12% vs. 24%; P = 0.004) and diabetics (5% vs. 11%; P = 0.04). The presence of pruritus was associated with a lower rate of arterial thrombosis, both at diagnosis (8% vs. 17%; P = 0.01) and during follow-up (16% vs. 30%; P = 0.003). Multivariable analysis revealed that these associations were independent of other risk factors for thrombosis. High JAK2V617F allele burden clustered with pruritus (P = 0.002) but did not affect thrombosis rates.
DOI of Published Version
10.1002/ajh.21156
Source
Am J Hematol. 2008 Jun;83(6):451-3. Link to article on publisher's site
Journal/Book/Conference Title
American journal of hematology
Related Resources
PubMed ID
18257107
Repository Citation
Gangat N, Strand JJ, Lasho TL, Li C, Pardanani AD, Tefferi A. (2008). Pruritus in polycythemia vera is associated with a lower risk of arterial thrombosis. GSBS Student Publications. https://doi.org/10.1002/ajh.21156. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1446