GSBS Student Publications

Title

Pruritus in polycythemia vera is associated with a lower risk of arterial thrombosis

Publication Date

2008-02-08

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Biochemistry and Molecular Biology; Program in Molecular Medicine

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Among 418 patients with polycythemia vera seen at our institution and in whom pruritus history was recorded, the presence of pruritus at diagnosis was documented in 131 (31%) and its absence in 287 (69%). Pruritus was less frequently reported by smokers (12% vs. 24%; P = 0.004) and diabetics (5% vs. 11%; P = 0.04). The presence of pruritus was associated with a lower rate of arterial thrombosis, both at diagnosis (8% vs. 17%; P = 0.01) and during follow-up (16% vs. 30%; P = 0.003). Multivariable analysis revealed that these associations were independent of other risk factors for thrombosis. High JAK2V617F allele burden clustered with pruritus (P = 0.002) but did not affect thrombosis rates.

DOI of Published Version

10.1002/ajh.21156

Source

Am J Hematol. 2008 Jun;83(6):451-3. Link to article on publisher's site

Journal/Book/Conference Title

American journal of hematology

Related Resources

Link to Article in PubMed

PubMed ID

18257107

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