Title
Cytogenetic studies at diagnosis in polycythemia vera: clinical and JAK2V617F allele burden correlates
UMMS Affiliation
Department of Biochemistry and Molecular Biology; Program in Molecular Medicine
Publication Date
2007-12-18
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
The prognostic significance of cytogenetic findings at diagnosis in polycythemia vera (PV) was investigated in a retrospective series of 137 patients. Cytogenetics were normal in 117 patients (85%) and displayed a -Y abnormality in five patients (7% of male patients), and other chromosomal abnormalities in 15 patients (11%). The most frequent cytogenetic anomalies were trisomy 8 (n = 4), trisomy 9 (n = 2), deletion 20q (n = 2) and chromosomal 1 abnormalities (n = 2). Parameters that were significantly associated with abnormal cytogenetics included age > or = 60 yr (P = 0.02), but not JAK2V617F allele burden, thrombosis, hemorrhage, leukemic/fibrotic transformation, or survival. We conclude that cytogenetic anomalies occur infrequently at PV diagnosis and do not confer an adverse outcome.
DOI of Published Version
10.1111/j.1600-0609.2007.01003.x
Source
Eur J Haematol. 2008 Mar;80(3):197-200. Epub 2007 Dec 7. Link to article on publisher's site
Journal/Book/Conference Title
European journal of haematology
Related Resources
PubMed ID
18081705
Repository Citation
Gangat N, Strand JJ, Lasho TL, Finke CM, Knudson RA, Pardanani AD, Li C, Ketterling RP, Tefferi A. (2007). Cytogenetic studies at diagnosis in polycythemia vera: clinical and JAK2V617F allele burden correlates. GSBS Student Publications. https://doi.org/10.1111/j.1600-0609.2007.01003.x. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1423