Cytogenetic studies at diagnosis in polycythemia vera: clinical and JAK2V617F allele burden correlates
Department of Biochemistry and Molecular Biology; Program in Molecular Medicine
Life Sciences | Medicine and Health Sciences
The prognostic significance of cytogenetic findings at diagnosis in polycythemia vera (PV) was investigated in a retrospective series of 137 patients. Cytogenetics were normal in 117 patients (85%) and displayed a -Y abnormality in five patients (7% of male patients), and other chromosomal abnormalities in 15 patients (11%). The most frequent cytogenetic anomalies were trisomy 8 (n = 4), trisomy 9 (n = 2), deletion 20q (n = 2) and chromosomal 1 abnormalities (n = 2). Parameters that were significantly associated with abnormal cytogenetics included age > or = 60 yr (P = 0.02), but not JAK2V617F allele burden, thrombosis, hemorrhage, leukemic/fibrotic transformation, or survival. We conclude that cytogenetic anomalies occur infrequently at PV diagnosis and do not confer an adverse outcome.
DOI of Published Version
Eur J Haematol. 2008 Mar;80(3):197-200. Epub 2007 Dec 7. Link to article on publisher's site
European journal of haematology
Gangat N, Strand JJ, Lasho TL, Finke CM, Knudson RA, Pardanani AD, Li C, Ketterling RP, Tefferi A. (2007). Cytogenetic studies at diagnosis in polycythemia vera: clinical and JAK2V617F allele burden correlates. Morningside Graduate School of Biomedical Sciences Student Publications. https://doi.org/10.1111/j.1600-0609.2007.01003.x. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1423