Title
Natural killer cells are not required for interferon-mediated prophylaxis against vaccinia or murine cytomegalovirus infections
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Pathology
Publication Date
1987-08-01
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Natural killer (NK) cell-depleted or control mice were treated prophylactically with polyinosinic: polycytidylic acid (polyI: polyC) or purified beta interferon (IFN) and then infected with either vaccinia virus or murine cytomegalovirus. NK cell depletion alone enhanced virus titres in the spleen and peritoneal cavity. However, poly I: polyC and IFN inhibited virus replication equally well in control and NK cell-depleted mice. This suggests that prophylactic IFN treatment mediates antiviral effects independently of NK cells.
DOI of Published Version
10.1099/0022-1317-68-8-2219
Source
J Gen Virol. 1987 Aug;68 ( Pt 8):2219-22.
Journal/Book/Conference Title
The Journal of general virology
Related Resources
PubMed ID
3039047
Repository Citation
Bukowski JF, McIntyre KW, Yang H, Welsh RM. (1987). Natural killer cells are not required for interferon-mediated prophylaxis against vaccinia or murine cytomegalovirus infections. GSBS Student Publications. https://doi.org/10.1099/0022-1317-68-8-2219. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/142