Natural killer cells are not required for interferon-mediated prophylaxis against vaccinia or murine cytomegalovirus infections
Graduate School of Biomedical Sciences; Department of Pathology
Medical Subject Headings
Animals; Cytomegalovirus Infections; Female; Interferon Type I; Killer Cells, Natural; Mice; Mice, Inbred C57BL; Poly I-C; Vaccinia
Life Sciences | Medicine and Health Sciences
Natural killer (NK) cell-depleted or control mice were treated prophylactically with polyinosinic: polycytidylic acid (polyI: polyC) or purified beta interferon (IFN) and then infected with either vaccinia virus or murine cytomegalovirus. NK cell depletion alone enhanced virus titres in the spleen and peritoneal cavity. However, poly I: polyC and IFN inhibited virus replication equally well in control and NK cell-depleted mice. This suggests that prophylactic IFN treatment mediates antiviral effects independently of NK cells.
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Citation: J Gen Virol. 1987 Aug;68 ( Pt 8):2219-22.
The Journal of general virology
Bukowski, Jack F.; McIntyre, Kim W.; Yang, Hyekyung; and Welsh, Raymond M., "Natural killer cells are not required for interferon-mediated prophylaxis against vaccinia or murine cytomegalovirus infections" (1987). GSBS Student Publications. 142.