Natural killer cells are not required for interferon-mediated prophylaxis against vaccinia or murine cytomegalovirus infections
Graduate School of Biomedical Sciences; Department of Pathology
Life Sciences | Medicine and Health Sciences
Natural killer (NK) cell-depleted or control mice were treated prophylactically with polyinosinic: polycytidylic acid (polyI: polyC) or purified beta interferon (IFN) and then infected with either vaccinia virus or murine cytomegalovirus. NK cell depletion alone enhanced virus titres in the spleen and peritoneal cavity. However, poly I: polyC and IFN inhibited virus replication equally well in control and NK cell-depleted mice. This suggests that prophylactic IFN treatment mediates antiviral effects independently of NK cells.
DOI of Published Version
J Gen Virol. 1987 Aug;68 ( Pt 8):2219-22.
The Journal of general virology
Bukowski JF, McIntyre KW, Yang H, Welsh RM. (1987). Natural killer cells are not required for interferon-mediated prophylaxis against vaccinia or murine cytomegalovirus infections. Morningside Graduate School of Biomedical Sciences Student Publications. https://doi.org/10.1099/0022-1317-68-8-2219. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/142