GSBS Student Publications

Title

Natural killer cells are not required for interferon-mediated prophylaxis against vaccinia or murine cytomegalovirus infections

Publication Date

1987-08-01

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Pathology

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Natural killer (NK) cell-depleted or control mice were treated prophylactically with polyinosinic: polycytidylic acid (polyI: polyC) or purified beta interferon (IFN) and then infected with either vaccinia virus or murine cytomegalovirus. NK cell depletion alone enhanced virus titres in the spleen and peritoneal cavity. However, poly I: polyC and IFN inhibited virus replication equally well in control and NK cell-depleted mice. This suggests that prophylactic IFN treatment mediates antiviral effects independently of NK cells.

Source

J Gen Virol. 1987 Aug;68 ( Pt 8):2219-22.

Journal/Book/Conference Title

The Journal of general virology

Related Resources

Link to article in PubMed

PubMed ID

3039047

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