Influenza A virus matrix protein 1-specific human CD8+ T-cell response induced in trivalent inactivated vaccine recipients
Graduate School of Biomedical Sciences; Center for Infectious Disease and Vaccine Research
Life Sciences | Medicine and Health Sciences
Among 17 HLA-A2-positive healthy adults, CD8+ T-cell responses against an HLA-A2-restricted matrix protein 1 (M1) epitope increased after immunization with trivalent inactivated influenza vaccine (TIV) in two individuals. The presence of M1 in TIV was confirmed by Western blotting. T-cell cytotoxicity assays showed that TIV is processed and the epitope is presented by antigen-presenting cells to an M1 epitope-specific CD8+ T-cell line for specific lysis. These data show that TIV, which is formulated to contain surface glycoproteins to induce serotype-specific antibody responses, also contains M1, capable of inducing subtype cross-reactive CD8+ T-cell responses in some vaccinees.
DOI of Published Version
J Virol. 2008 Sep;82(18):9283-7. Epub 2008 Jul 9. Link to article on publisher's site
Journal of virology
Terajima M, Cruz J, Leporati AM, Orphin L, Babon JA, Co MD, Pazoles PP, Jameson JM, Ennis FA. (2008). Influenza A virus matrix protein 1-specific human CD8+ T-cell response induced in trivalent inactivated vaccine recipients. Morningside Graduate School of Biomedical Sciences Student Publications. https://doi.org/10.1128/JVI.01047-08. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1380