Academic Program
Neuroscience
UMMS Affiliation
Department of Neurobiology; Waddell Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Publication Date
2008-03-19
Document Type
Article
Disciplines
Behavioral Neurobiology
Abstract
In Drosophila, formation of aversive olfactory long-term memory (LTM) requires multiple training sessions pairing odor and electric shock punishment with rest intervals. In contrast, here we show that a single 2 min training session pairing odor with a more ethologically relevant sugar reinforcement forms long-term appetitive memory that lasts for days. Appetitive LTM has some mechanistic similarity to aversive LTM in that it can be disrupted by cycloheximide, the dCreb2-b transcriptional repressor, and the crammer and tequila LTM-specific mutations. However, appetitive LTM is completely disrupted by the radish mutation that apparently represents a distinct mechanistic phase of consolidated aversive memory. Furthermore, appetitive LTM requires activity in the dorsal paired medial neuron and mushroom body alpha'beta' neuron circuit during the first hour after training and mushroom body alphabeta neuron output during retrieval, suggesting that appetitive middle-term memory and LTM are mechanistically linked. Last, experiments feeding and/or starving flies after training reveals a critical motivational drive that enables appetitive LTM retrieval.
Rights and Permissions
Publisher PDF posted as allowed by the publisher's author rights policy at http://www.jneurosci.org/site/misc/ifa_policies.xhtml#copyright. Copyright of all material published in The Journal of Neuroscience remains with the authors. The authors grant the Society for Neuroscience an exclusive license to publish their work for the first 6 months. After 6 months the work becomes available to the public to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license.
DOI of Published Version
10.1523/JNEUROSCI.5333-07.2008
Source
J Neurosci. 2008 Mar 19;28(12):3103-13. Link to article on publisher's site
Journal/Book/Conference Title
The Journal of neuroscience : the official journal of the Society for Neuroscience
Related Resources
PubMed ID
18354013
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Repository Citation
Krashes MJ, Waddell S. (2008). Rapid consolidation to a radish and protein synthesis-dependent long-term memory after single-session appetitive olfactory conditioning in Drosophila. GSBS Student Publications. https://doi.org/10.1523/JNEUROSCI.5333-07.2008. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1341