GSBS Student Publications

Title

Apoptosis and loss of virus-specific CD8+ T-cell memory

Publication Date

2004-05-12

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Pathology

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

CD8(+) T-cell memory to viruses is stable in the absence but volatile in the presence of other infections. Apoptotic events that occur early in acute infections delete pre-existing memory T cells, leaving the host with reduced memory (except for cross-reactive responses) to previously encountered viruses. Apoptotic events also silence the acute immune response, leaving the host with a residual population of memory T cells. Persistent infections can induce apoptotic deletions of memory T cells that are specific to the persisting virus and to previously encountered pathogens.

DOI of Published Version

10.1016/j.coi.2004.03.020

Source

Curr Opin Immunol. 2004 Jun;16(3):271-6. Link to article on publisher's site

Journal/Book/Conference Title

Current opinion in immunology

Related Resources

Link to Article in PubMed

PubMed ID

15134774

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