Title
Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs
Academic Program
Biochemistry & Molecular Pharmacology
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Pathology
Publication Date
2003-05-20
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response, and their presence in the periphery is important for resistance to secondary challenge. We show here that LCMV-specific T cells in peripheral tissue (peritoneal cavity, lung, fat pads) reacted much less with the apoptotic marker Annexin-V than those in spleen and lymph nodes. This was not due to a TCR-based selection. In comparison to lymphoid tissue, T cells in the periphery expressed lower levels of Fas and Fas ligand and were resistant to activation-induced cell death in vitro. This may contribute to the survival of nondividing peripheral memory T cells, enabling them to efficiently function without being driven into apoptosis.
DOI of Published Version
10.1016/S1074-7613(03)00116-X
Source
Immunity. 2003 May;18(5):631-42.
Journal/Book/Conference Title
Immunity
Related Resources
PubMed ID
12753740
Repository Citation
Wang XZ, Stepp SE, Brehm MA, Chen HD, Selin LK, Welsh RM. (2003). Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs. GSBS Student Publications. https://doi.org/10.1016/S1074-7613(03)00116-X. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1327