GSBS Student Publications

Title

Multiple mouse chromosomal loci for dynein-based motility

Publication Date

1996-08-15

UMMS Affiliation

Graduate School of Biomedical Sciences; Cell Biology Group; Department of Cell Biology

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Dyneins are multisubunit mechanochemical enzymes capable of interacting with microtubules to generate force. Axonemal dyneins produce the motive force for ciliary and flagellar beating by inducing sliding between adjacent microtubules within the axoneme. Cytoplasmic dyneins translocate membranous organelles and chromosomes toward the minus ends of cytoplasmic microtubules. Dynactin is an accessory complex implicated in tethering cytoplasmic dynein to membranous organelles and mitotic kinetochores. In the studies described here, we have identified a number of new dynein genes and determined their mouse chromosomal locations by interspecific backcross analysis. We have also mapped several dynein and dynactin genes cloned previously. Our studies provide the first comprehensive attempt to map dynein and dynactin genes in mammals and provide a basis for the further analysis of dynein function in development and disease.

DOI of Published Version

10.1006/geno.1996.0422

Source

Genomics. 1996 Aug 15;36(1):29-38. Link to article on publisher's site

Journal/Book/Conference Title

Genomics

Related Resources

Link to Article in PubMed

PubMed ID

8812413

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