Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades
Graduate School of Biomedical Sciences; Program in Molecular Medicine
Life Sciences | Medicine and Health Sciences
Mixed-lineage protein kinase 3 (MLK3) is a member of the mitogen-activated protein (MAP) kinase kinase kinase group that has been implicated in multiple signaling cascades, including the NF-kappaB pathway and the extracellular signal-regulated kinase, c-Jun NH(2)-terminal kinase (JNK), and p38 MAP kinase pathways. Here, we examined the effect of targeted disruption of the murine Mlk3 gene. Mlk3(-/-) mice were found to be viable and healthy. Primary embryonic fibroblasts prepared from these mice exhibited no major signaling defects. However, we did find that MLK3 deficiency caused a selective reduction in tumor necrosis factor (TNF)-stimulated JNK activation. Together, these data demonstrate that MLK3 contributes to the TNF signaling pathway that activates JNK.
DOI of Published Version
Mol Cell Biol. 2005 May;25(9):3670-81. Link to article on publisher's site
Molecular and cellular biology
Brancho DM, Ventura J, Jaeschke A, Doran B, Flavell RA, Davis RJ. (2005). Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades. GSBS Student Publications. https://doi.org/10.1128/MCB.25.9.3670-3681.2005. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/127