GSBS Student Publications
Title
fMRI of generalized absence status epilepticus in conscious marmoset monkeys reveals corticothalamic activation
GSBS Program
Neuroscience
Publication Date
2004-10-06
UMMS Affiliation
Center for Comparative Neuroimaging, Department of Psychiatry; Department of Pediatrics
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences | Neurology | Neuroscience and Neurobiology | Psychiatry
Abstract
PURPOSE: A nonhuman primate model of generalized absence status epilepticus was developed for use in functional magnetic resonance imaging (fMRI) experiments to elucidate the brain mechanisms underlying this disorder.
METHODS: Adult male marmoset monkeys (Callithrix jacchus) were treated with gamma-butyrolactone (GBL) to induce prolonged absence seizures, and the resulting spike-wave discharges (SWDs) were analyzed to determine the similarity to the 3-Hz SWDs that characterize the disorder. In addition, blood-oxygenation-level-dependent (BOLD) fMRI was measured at 4.7 Tesla after absence seizure induction with GBL.
RESULTS: Electroencephalographic recordings during imaging showed 3-Hz SWDs typical of human absence seizures. This synchronized EEG pattern started within 15 to 20 min of drug administration and persisted for >60 min. In addition, pretreatment with the antiepileptic drug, ethosuximide (ESM), blocked the behavioral and EEG changes caused by GBL. Changes in BOLD signal intensity in the thalamus and sensorimotor cortex correlated with the onset of 3-Hz SWDs. The change in BOLD signal intensity was bilateral but heterogeneous, affecting some brain areas more than others. No significant negative BOLD changes were seen.
CONCLUSIONS: The BOLD fMRI data obtained in this marmoset monkey model of absence status epilepticus shows activation within the thalamus and cortex.
DOI of Published Version
10.1111/j.0013-9580.2004.21504.x
Source
Epilepsia. 2004 Oct;45(10):1240-7. Link to article on publisher's site
Journal/Book/Conference Title
Epilepsia
Related Resources
PubMed ID
15461678
Repository Citation
Tenney JR, Marshall PC, King JA, Ferris CF. (2004). fMRI of generalized absence status epilepticus in conscious marmoset monkeys reveals corticothalamic activation. GSBS Student Publications. https://doi.org/10.1111/j.0013-9580.2004.21504.x. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1242