Title

Corticothalamic modulation during absence seizures in rats: a functional MRI assessment

GSBS Program

Biochemistry & Molecular Pharmacology

Publication Date

2003-08-16

UMMS Affiliation

Graduate School of Biomedical Sciences; Center for Comparative Neuroimaging; Department of Psychiatry

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

PURPOSE: Functional magnetic resonance imaging (fMRI) was used to identify areas of brain activation during absence seizures in an awake animal model.

METHODS: Blood-oxygenation-level-dependent (BOLD) fMRI in the brain was measured by using T2*-weighted echo planar imaging at 4.7 Tesla. BOLD imaging was performed before, during, and after absence seizure induction by using gamma-butyrolactone (GBL; 200 mg/kg, intraperitoneal).

RESULTS: The corticothalamic circuitry, critical for spike-wave discharge (SWD) formation in absence seizure, showed robust BOLD signal changes after GBL administration, consistent with EEG recordings in the same animals. Predominantly positive BOLD changes occurred in the thalamus. Sensory and parietal cortices showed mixed positive and negative BOLD changes, whereas temporal and motor cortices showed only negative BOLD changes.

CONCLUSIONS: With the BOLD fMRI technique, we demonstrated signal changes in brain areas that have been shown, with electrophysiology experiments, to be important for generating and maintaining the SWDs that characterize absence seizures. These results corroborate previous findings from lesion and electrophysiological experiments and show the technical feasibility of noninvasively imaging absence seizures in fully conscious rodents.

DOI of Published Version

10.1046/j.1528-1157.2003.61002.x

Source

Epilepsia. 2003 Sep;44(9):1133-40.

Journal/Book/Conference Title

Epilepsia

Related Resources

Link to Article in PubMed

PubMed ID

12919383

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