Control of infections by NK cells

Student Author(s)

Chin Hun Tay

Academic Program

Immunology and Microbiology

UMMS Affiliation

Department of Pathology

Publication Date


Document Type

Book Chapter


Immunology and Infectious Disease


The natural immune system consists of preexisting or rapidly inducible effector components as a first line of defense against pathogens to which the host has not previously been exposed. Such a system is necessary as the B and T cell specific responses to any pathogen require the selective expansion of high-affinity antigen-specific clones which take several days to develop. An unimpeded replication of a virus producing 105 progeny per cell could potentially infect all of the cells in the host after only three or four replication cycles. Without the natural immune system holding infections in check, pathogens could overwhelm the host before the T and B cell responses become effective.


Natural Killer Cell, MCMV Infection, Natural Killer Gene Complex, Transporter Associate With Antigen Presentation

DOI of Published Version



Tay CH, Szomolanyi-Tsuda E, Welsh RM. Control of infections by NK cells. Curr Top Microbiol Immunol. 1998;230:193-220. doi: 10.1007/978-3-642-46859-9_12. PMID: 9586357.

Journal/Book/Conference Title

Current topics in microbiology and immunology

Related Resources

Link to Article in PubMed

PubMed ID