Control of infections by NK cells
Immunology and Microbiology
Department of Pathology
Immunology and Infectious Disease
The natural immune system consists of preexisting or rapidly inducible effector components as a first line of defense against pathogens to which the host has not previously been exposed. Such a system is necessary as the B and T cell specific responses to any pathogen require the selective expansion of high-affinity antigen-specific clones which take several days to develop. An unimpeded replication of a virus producing 105 progeny per cell could potentially infect all of the cells in the host after only three or four replication cycles. Without the natural immune system holding infections in check, pathogens could overwhelm the host before the T and B cell responses become effective.
Natural Killer Cell, MCMV Infection, Natural Killer Gene Complex, Transporter Associate With Antigen Presentation
DOI of Published Version
Tay CH, Szomolanyi-Tsuda E, Welsh RM. Control of infections by NK cells. Curr Top Microbiol Immunol. 1998;230:193-220. doi: 10.1007/978-3-642-46859-9_12. PMID: 9586357.
Current topics in microbiology and immunology
Tay CH, Szomolanyi-Tsuda E, Welsh RM. (1998). Control of infections by NK cells. GSBS Student Publications. https://doi.org/10.1007/978-3-642-46859-9_12. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1233