Title
Effects of striatal excitotoxicity on huntingtin-like immunoreactivity
UMMS Affiliation
Graduate School of Biomedical Sciences; Neuroregeneration Laboratory
Publication Date
1995-05-30
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
The relationship between the specific neuronal loss observed in Huntington's disease and the mutation in the IT15 gene responsible for this disease remains obscure. Using an antipeptide antibody against amino acids 3114-3141 of the human huntington protein, we demonstrate that striatal injection of quinolinic acid in mice induces increased immunoreactivity for huntington in some remaining neurons but not in glial cells. This increase is apparent in both neuronal cell bodies and in cell processes in the white matter six hours after excitotoxic challenge. This finding suggests that huntington may be involved in the response to excitotoxic stress in these neurons.
Source
Neuroreport. 1995 May 30;6(8):1125-9.
Journal/Book/Conference Title
Neuroreport
Related Resources
PubMed ID
7662892
Repository Citation
Tatter SB, Galpern WR, Hoogeveen AT, Isacson O. (1995). Effects of striatal excitotoxicity on huntingtin-like immunoreactivity. GSBS Student Publications. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1231