Title
Major histocompatibility complex class I-restricted cytotoxic T lymphocyte responses to Epstein-Barr virus in children
Academic Program
Biochemistry & Molecular Pharmacology
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Pediatrics
Publication Date
1995-09-01
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Epstein-Barr virus (EBV)-specific cytotoxic T lymphocyte (CTL) responses were evaluated in 9 children aged 20-35 months. Autologous EBV-transformed B lymphoblastoid cell lines were used to restimulate EBV-specific memory CTL precursors in vitro. Recognition of individual EBV gene products by bulk CTL lines was evaluated by combining CTL lines with B cell blasts infected with recombinant vaccinia constructs expressing single latent genes. CTL lines from all 9 children recognized one or more EBV latent gene products. All children demonstrated CTL responses against one or more EBV nuclear antigen 3 proteins (EBNA3A, 3B, 3C), and EBNA3C was recognized most frequently. The striking similarity between EBV-specific CTL responses described here in young children and those reported for adults suggests that the EBNA3 family of proteins and latent membrane protein 2A should be considered for inclusion in candidate EBV vaccines.
DOI of Published Version
10.1093/infdis/172.3.739
Source
J Infect Dis. 1995 Sep;172(3):739-46.
Journal/Book/Conference Title
The Journal of infectious diseases
Related Resources
PubMed ID
7658067
Repository Citation
Tamaki H, Beaulieu BL, Somasundaran M, Sullivan JL. (1995). Major histocompatibility complex class I-restricted cytotoxic T lymphocyte responses to Epstein-Barr virus in children. GSBS Student Publications. https://doi.org/10.1093/infdis/172.3.739. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1225