GSBS Student Publications


The roles of DNA polymerases alpha and delta in DNA replication

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Pharmacology; Department of Biochemistry and Molecular Pharmacology



Document Type


Medical Subject Headings

Animals; DNA Polymerase II; DNA Polymerase III; DNA Replication; DNA-Directed DNA Polymerase


Life Sciences | Medicine and Health Sciences


The identities and precise roles of the DNA polymerase(s) involved in mammalian cell DNA replication are uncertain. Circumstantial evidence suggests that DNA polymerase alpha and at least one form of DNA polymerase delta, that which is stimulated by Proliferating Cell Nuclear Antigen, catalyze mammalian cell replicative DNA synthesis. Further, the in vitro properties of polymerases alpha and delta suggest a model for their coordinate action at the replication fork. The present paper summarizes the current status of DNA polymerases alpha and delta in DNA replication, and describes newly available approaches to the study of those enzymes.

Rights and Permissions

Citation: Pharmacol Ther. 1990;47(1):105-15.

Related Resources

Link to Article in PubMed

Journal Title

Pharmacology and therapeutics

PubMed ID