Title
Bone marrow cells as the origin of stomach cancer
Academic Program
Cancer Biology
UMMS Affiliation
Department of Medicine, Division of Gastroenterology
Publication Date
2006-03-25
Document Type
Article
Disciplines
Gastroenterology | Life Sciences | Medicine and Health Sciences
Abstract
Cells derived from bone marrow are pluripotent, with the ability to differentiate into multiple cell types. Environmental cues dictate differentiation decisions. It should not be surprising then, that abnormal cell environments lead to abnormal differentiation of these cells, and in some cases, malignant transformation. Identifying a role for bone marrow-derived cells in the initiation and progression of cancer allows a dramatic change in the way in which cancer is viewed. Identifying the cell responsible for initiating a tumor offers the exciting possibility of specifically targeting unique aspects of these cells and altering signaling properties for more effective therapeutic approaches.
DOI of Published Version
10.2217/14796694.1.6.851
Source
Future Oncol. 2005 Dec;1(6):851-62. Link to article on publisher's site
Journal/Book/Conference Title
Future oncology (London, England)
Related Resources
PubMed ID
16556065
Repository Citation
Stoicov C, Li H, Carlson JE, Houghton J. (2006). Bone marrow cells as the origin of stomach cancer. GSBS Student Publications. https://doi.org/10.2217/14796694.1.6.851. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1206