GSBS Student Publications

Title

Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganization

Publication Date

2001-01-09

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Molecular Medicine and the Department of Molecular Genetics and Microbiology

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

In Drosophila syncytial blastoderm embryos, centrosomes specify the position of actin-based interphase caps and mitotic furrows. Mutations in the scrambled locus prevent assembly of mitotic furrows, but do not block actin cap formation. The scrambled gene encodes a protein that localizes to the mitotic furrows and centrosomes. Sced localization, actin reorganization from caps into mitotic furrows, and centrosome-coordinated assembly of actin caps are not blocked by microtubule disruption. Our results indicate that centrosomes may coordinate assembly of cortical actin caps through a microtubule-independent mechanism, and that Scrambled mediates a second microtubule-independent process that drives mitotic furrow assembly.

DOI of Published Version

10.1038/35050579

Source

Nat Cell Biol. 2001 Jan;3(1):68-75. Link to article on publisher's site

Journal/Book/Conference Title

Nature cell biology

Related Resources

Link to Article in PubMed

PubMed ID

11146628

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