GSBS Student Publications


Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganization

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Molecular Medicine and the Department of Molecular Genetics and Microbiology



Document Type


Medical Subject Headings

Actins; Animals; Blastoderm; Cell Cycle Proteins; Centrosome; Colchicine; Cytochalasin D; Cytoskeleton; Drosophila; *Drosophila Proteins; Embryo, Nonmammalian; Insect Proteins; Interphase; Microtubules; Mitosis; Mutation; Polymers


Life Sciences | Medicine and Health Sciences


In Drosophila syncytial blastoderm embryos, centrosomes specify the position of actin-based interphase caps and mitotic furrows. Mutations in the scrambled locus prevent assembly of mitotic furrows, but do not block actin cap formation. The scrambled gene encodes a protein that localizes to the mitotic furrows and centrosomes. Sced localization, actin reorganization from caps into mitotic furrows, and centrosome-coordinated assembly of actin caps are not blocked by microtubule disruption. Our results indicate that centrosomes may coordinate assembly of cortical actin caps through a microtubule-independent mechanism, and that Scrambled mediates a second microtubule-independent process that drives mitotic furrow assembly.

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Citation: Nat Cell Biol. 2001 Jan;3(1):68-75. Link to article on publisher's site

DOI of Published Version


Related Resources

Link to Article in PubMed

Journal Title

Nature cell biology

PubMed ID