Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganization
Graduate School of Biomedical Sciences; Program in Molecular Medicine and the Department of Molecular Genetics and Microbiology
Life Sciences | Medicine and Health Sciences
In Drosophila syncytial blastoderm embryos, centrosomes specify the position of actin-based interphase caps and mitotic furrows. Mutations in the scrambled locus prevent assembly of mitotic furrows, but do not block actin cap formation. The scrambled gene encodes a protein that localizes to the mitotic furrows and centrosomes. Sced localization, actin reorganization from caps into mitotic furrows, and centrosome-coordinated assembly of actin caps are not blocked by microtubule disruption. Our results indicate that centrosomes may coordinate assembly of cortical actin caps through a microtubule-independent mechanism, and that Scrambled mediates a second microtubule-independent process that drives mitotic furrow assembly.
DOI of Published Version
Nat Cell Biol. 2001 Jan;3(1):68-75. Link to article on publisher's site
Nature cell biology
Stevenson VA, Kramer J, Kuhn J, Theurkauf WE. (2001). Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganization. Morningside Graduate School of Biomedical Sciences Student Publications. https://doi.org/10.1038/35050579. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1202