Title
Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganization
UMMS Affiliation
Graduate School of Biomedical Sciences; Program in Molecular Medicine and the Department of Molecular Genetics and Microbiology
Publication Date
2001-01-09
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
In Drosophila syncytial blastoderm embryos, centrosomes specify the position of actin-based interphase caps and mitotic furrows. Mutations in the scrambled locus prevent assembly of mitotic furrows, but do not block actin cap formation. The scrambled gene encodes a protein that localizes to the mitotic furrows and centrosomes. Sced localization, actin reorganization from caps into mitotic furrows, and centrosome-coordinated assembly of actin caps are not blocked by microtubule disruption. Our results indicate that centrosomes may coordinate assembly of cortical actin caps through a microtubule-independent mechanism, and that Scrambled mediates a second microtubule-independent process that drives mitotic furrow assembly.
DOI of Published Version
10.1038/35050579
Source
Nat Cell Biol. 2001 Jan;3(1):68-75. Link to article on publisher's site
Journal/Book/Conference Title
Nature cell biology
Related Resources
PubMed ID
11146628
Repository Citation
Stevenson VA, Kramer J, Kuhn J, Theurkauf WE. (2001). Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganization. GSBS Student Publications. https://doi.org/10.1038/35050579. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1202