Title

Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair

Academic Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology

Publication Date

2003-10-24

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The organization and sorting of regulatory information for transcription, replication and repair depends on components of nuclear architecture. It is necessary, therefore, to understand cellular processes within the context of intranuclear microenvironments that mediate the focal assembly of the machinery for transcription, replication and repair and which facilitate the orchestration of these essential processes. Here, we discuss how nuclear anatomy supports the temporal and spatial coordination of regulatory protein recruitment for combinatorial control.

DOI of Published Version

10.1016/j.tcb.2003.09.009

Source

Trends Cell Biol. 2003 Nov;13(11):584-92.

Journal/Book/Conference Title

Trends in cell biology

Related Resources

Link to Article in PubMed

PubMed ID

14573352

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