GSBS Student Publications


Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology



Document Type


Medical Subject Headings

Animals; Apoptosis; Cell Nucleus; DNA Methylation; *DNA Repair; *DNA Replication; *Gene Expression Regulation; Humans; Models, Genetic; Nuclear Matrix


Life Sciences | Medicine and Health Sciences


The organization and sorting of regulatory information for transcription, replication and repair depends on components of nuclear architecture. It is necessary, therefore, to understand cellular processes within the context of intranuclear microenvironments that mediate the focal assembly of the machinery for transcription, replication and repair and which facilitate the orchestration of these essential processes. Here, we discuss how nuclear anatomy supports the temporal and spatial coordination of regulatory protein recruitment for combinatorial control.

Rights and Permissions

Citation: Trends Cell Biol. 2003 Nov;13(11):584-92.

Related Resources

Link to Article in PubMed

Journal Title

Trends in cell biology

PubMed ID