GSBS Student Publications
Title
Interrelationships of nuclear structure and transcriptional control: functional consequences of being in the right place at the right time
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center
Date
7-22-1998
Document Type
Article
Medical Subject Headings
Amino Acid Sequence; Animals; Cell Nucleus; *Gene Expression Regulation; Humans; Molecular Sequence Data; Nuclear Matrix; Transcription Factors; Transcription, Genetic
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Functional interrelationships between components of nuclear architecture and control of gene expression are becoming increasingly evident. In this article we focus on the concept that association of genes and cognate transcription factors with the nuclear matrix may support the formation and/or activities of nuclear domains that facilitate transcriptional regulation. Several lines of evidence are consistent with the concept that association of transcription factors with the nuclear matrix may be obligatory for fidelity of gene expression and maximal transcriptional activity. The identification of specific regions of transcription factors that are responsible for intranuclear trafficking to nuclear matrix-associated sites that support transcription, reinforces the linkage of nuclear structure to regulation of genes. CBFA2/AML-1 and CBFA1/AML-3 provide paradigms for directing gene regulatory factors to RNA polymerase II containing foci within the nucleus. The implications of modifications in the intranuclear trafficking of transcription factors for developmental and tissue-specific control, as well as for aberrations in gene expression that are associated with cancer and neurological disorders, are addressed.
Rights and Permissions
Citation: J Cell Biochem. 1998 Aug 1;70(2):200-12.
Related Resources
Journal Title
Journal of cellular biochemistry
PubMed ID
9671226
Repository Citation
Stein, Gary S.; Van Wijnen, Andre J.; Stein, Janet L.; Lian, Jane B.; Pockwinse, Shirwin M.; and McNeil, Sandra Marie, "Interrelationships of nuclear structure and transcriptional control: functional consequences of being in the right place at the right time" (1998). GSBS Student Publications. 1193.
https://escholarship.umassmed.edu/gsbs_sp/1193