Contributions of nuclear architecture to transcriptional control
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Department of Cell Biology
Medical Subject Headings
Animals; Cell Cycle; Cell Differentiation; Cell Nucleus; Histones; Humans; Osteoblasts; Osteocalcin; *Transcription, Genetic
Life Sciences | Medicine and Health Sciences
Three parameters of nuclear structure contribute to transcriptional control. The linear representation of promoter elements provides competency for physiological responsiveness within the contexts of development as well as cycle- and phenotype-dependent regulation. Chromatin structure and nucleosome organization reduce distances between independent regulatory elements providing a basis for integrating components of transcriptional control. The nuclear matrix supports gene expression by imposing physical constraints on chromatin related to three-dimensional genomic organization. In addition, the nuclear matrix facilitates gene localization as well as the concentration and targeting of transcription factors. Several lines of evidence are presented that are consistent with involvement of multiple levels of nuclear architecture in cell growth and tissue-specific gene expression during differentiation. Growth factor and steroid hormone responsive modifications in chromatin structure, nucleosome organization, and the nuclear matrix that influence transcription of the cell cycle-regulated histone gene and the bone tissue-specific osteocalcin gene during progressive expression of the osteoblast phenotype are considered.
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Citation: Int Rev Cytol. 1995;162A:251-78.
International review of cytology
Stein, Gary S.; Van Wijnen, Andre J.; Stein, Janet L.; Lian, Jane B.; and Montecino, Martin A., "Contributions of nuclear architecture to transcriptional control" (1995). GSBS Student Publications. 1188.